By: Oded Ben-Joseph, PhD, MBA and Echoe Bouta, PhD
Bacterial resistance is a huge and growing unmet need. However, Novartis’ recent announcement that the company is shutting down its antibacterial and antiviral research — followed by similar moves from Eli Lilly, Bristol-Myers Squibb and AstraZeneca — presents a sector-wide trend. This big pharma flight from anti-infective R&D will create significant challenges for early-stage biotech companies seeking to develop novel and much needed drugs in this sector, as opportunities for partnerships, joint R&D relationships, and merger/acquisition transactions are diminishing. This trend supports our internal research and analysis of the anti-infectives segment (J. Comm. Biotech., Vol 24, 2, 47-53).
Even when a company’s management and board is committed to the success of its endeavors, we often find they exhibit a tendency to disregard the dynamics of the segment in which they operate. Recently, we analyzed financing events, M&A transactions and initial public offerings (IPOs) from 2015-2017 in various separate sectors. Within that time period, the anti-infectives sector showed little opportunity for successful exit. Few M&As or IPOs were successfully completed, likely due to the low revenues earned by recently approved antibiotics. Of the limited number of exits that were achieved, the majority occurred when the lead asset was in Phase III trials or already approved. Most investors in the anti-infectives sector have experienced limited returns, and that experience challenges the ability of young companies to raise either private or public capital for new anti-infectives development. This finding is evidenced by the low number of funded companies in the sector, and by the total capital raised to support anti-infectives development compared to other industry segments.
Undercapitalization is a risk for any biotech company. Due to the challenges of raising capital and exiting successfully within this sector, that risk is further increased for anti-infective companies. This situation dictates a strategy of targeting large venture firms with sufficient capital to support the company to Phase III and beyond. Furthermore, these dynamics suggest that young companies should hold discussions early with prospective future buyers to determine those companies’ interest in their development strategy. Early partnering/collaboration as a risk mitigation measure is critical.
Tuesday, July 23 6:00-7:30pm Cost: This event is hosted by Dr. Oded Ben-Joseph (Darwin 1988), Managing Director, Outcome Capital, LLC, and is free to attend with prior RSVP. Outcome Capital, LLC 99 High Street, Suite 2900 Boston, MA RSVP to Megan Cokely at firstname.lastname@example.org Cambridge in America’s Boston Regional Committee invites you to another exclusive event for […]Read More
Outcome Capital Secures Growth Capital for Whisker Labs November 26, 2019, Reston, VA Outcome Capital, an investment banking firm that serves middle market growth companies in the technology and life sciences space, is pleased to announce that Whisker Labs, Inc. (the “Company”) has secured growth capital from State Farm Ventures and Ferguson Ventures along with […]Read More